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KMID : 0378019860290060121
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New Medical Journal
1986 Volume.29 No. 6 p.121 ~ p.126
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A double-blind randomizd study of the immunogenicity and reactogenicity of Tow doses of the recombinant DNA yeast-derived hepatitis B vaccine(Smith Kline-RIT) in healthy young adults
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Abstract
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A double-blind randomized study of the immunogenicity and reactogenicity of a 10-mcg and a 20-mcg dose of lot of the Smith Kline-RIT recombinant DNA yeast-derived hepatitis h vaccine was conducted in young adults without markers of previous hepatitis B infection. Immunization was carried out according to a 0-, 1-, and 6-month vaccination schedule.
Results indicated that the yeast-derived hepatitis B vaccine was of low reactogenicity :and high immunogenicity. Reactogenicity to the yeast-derived vaccine was low in incidence and general reactions were short-lasting and mainly mild in severity. By (Re month after the third vaccine dose, the yeast-derived vaccine had induced a 100% seroc reversion rate in both groups. The anti-HBs geometric mean rebched 1246 and 1139.5 in he groups receiving the 10-and 20-mcg vaccine dose, respectively.
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KEYWORD
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